Personally, I agree with the general sentiment about RoundUp. I've never used it, and instead we've used other methods for weed control (none of which are perfect, but they're not toxic). And like some have said above, ours is not a region in which much herbicide or conventional pesticide is used by gardeners or farmers, though it was fairly common 40 years ago or so, I'm told.
But, having said that, I'll add something here... This happened more than a decade ago. We have some neighbors—good friends, in fact—who used RoundUp one season on an upper field they were planning to clear of weeds in prep for planting many varieties of potatoes (a commercial crop) the next year. Prior to this, they were basically organic gardeners with a largish family plot, greenhouses, and fruit trees.
So they did that and never used glyphosate again. They applied for "transitional status" toward commercial certified organic, and three years later they were able to obtain that status, since no more herbicide (or pesticide) was ever used in that field. So the certification, which required annual inspection and reporting, became continual.
I respect them. I might have tried rotovating the whole field every month or so, from mid spring to late fall. But I believe they had tried that. I'm not sure what I'd have done, and sometimes if you want to be organic, commercial, and cost-effective (all three) there seems to be no perfect solution.